World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Bovine Colostrum Increases Pore-forming Claudin-2 Protein Expression but Paradoxically Not Ion Permeability Possibly by a Change of the Intestinal Cytokine Milieu, Volume 8

By Boone, David, L.

Click here to view

Book Id: WPLBN0003944699
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Bovine Colostrum Increases Pore-forming Claudin-2 Protein Expression but Paradoxically Not Ion Permeability Possibly by a Change of the Intestinal Cytokine Milieu, Volume 8  
Author: Boone, David, L.
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Description
Description : An impaired intestinal barrier function is involved in the pathogenesis of inflammatory bowel disease (IBD). Several nutritional factors are supposed to be effective in IBD treatment but scientific data about the effects on the intestinal integrity remain scarce. Bovine colostrum was shown to exert beneficial effects in DSS-induced murine colitis, and the present study was undertaken to explore the underlying molecular mechanisms. Western blot revealed increased claudin-2 expression in the distal ileum of healthy mice after feeding with colostrum for 14 days, whereas other tight junction proteins (claudin-3, 4, 10, 15) remained unchanged. The colostrum-induced claudin-2 induction was confirmed in differentiated Caco-2 cells after culture with colostrum for 48 h. Paradoxically, the elevation of claudin-2, which forms a cation-selective pore, was neither accompanied by increased ion permeability nor impaired barrier function. In an in situ perfusion model, 1 h exposure of the colonic mucosa to colostrum induced significantly increased mRNA levels of barrier-strengthening cytokine transforming growth factor-b, while interleukine-2, interleukine-6, interleukine-10, interleukine-13, and tumornecrosis factor-a remained unchanged. Thus, modulation of the intestinal transforming growth factor-b expression might have compensated the claudin-2 increase and contributed to the observed barrier strengthening effects of colostrum in vivo and in vitro.

 

Click To View

Additional Books


  • Plos One : Habitat Characteristics of Fo... (by )
  • Plos One : Effects of Partial and Acute ... (by )
  • Plos One : Performance of Multiplex Cyto... (by )
  • Plos One : Adjuvant Chemotherapy, a Valu... (by )
  • Plos One : Molecular Basis for Involveme... (by )
  • Plos One : Activation of Fms-like Tyrosi... (by )
  • Plos One : Seed Servers ; High-performan... (by )
  • Plos One : ‘‘like Throwing a Bowling Bal... (by )
  • Plos One : Age-dependent Effects of A53T... (by )
  • Plos One : Heparin-binding Haemagglutini... (by )
  • Plos One : Quantifying Species Diversity... (by )
  • Plos One : a Longitudinal Study of Motor... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from Nook eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.